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via indeed · 5 juni 2026 ·för 1 dag sedan

Postdoctoral Researcher in Cancer Research focusing on intratumor heterogeneity and phenotypic plasticity

Karolinska Institutet (KI)

Solna

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Do you want to contribute to top quality medical research?
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The successful candidate will work on childhood neuroblastoma and paraganglioma in the research group headed by Susanne Schlisio:

The research is performed in an interdisciplinary setting with strong collaboration with clinical departments and other national and international research groups.

We are seeking a motivated, creative post\-doctoral candidate interested in exploring drivers of intratumor heterogeneity and phenotypic plasticity in childhood neuroblastoma and paraganglioma.

Intratumor heterogeneity and high plasticity account for therapy resistance. Causes of plasticity cell state transitions during tumor progression remain poorly understood. Currently, there is no effective treatment that addresses cancer heterogeneity. Systematic characterization of dynamic properties of intratumor heterogeneity and phenotypic plasticity can guide treatment strategies and improve clinical outcome for cancer patients. We aim at elucidating the origin and heterogeneity of paraganglioma and childhood neuroblastoma by developing a new analytic and experimental approach based on spatial transcriptomics and single\-cell transcriptomics with integrated mass spectrometry. We use organoids, cell lines and generate novel tumor mouse model systems and include human tumors to perform comparative differentiation trajectory analysis, to make predictions and, finally, to perform preliminary validations of envisioned tumor differentiation strategies.

In addition, we are also looking for motivated, creative post\-doctoral candidates interested in cancer metabolism with knowledge in mitochondrial biology, biochemistry and molecular biology. We currently defining how mitochondrial dynamics and mass is related to cancer therapy resistance.

Your mission

We offer a highly interdisciplinary environment , integrating computational biology with cancer and developmental biology. We develop new analytic and experimental approaches based on single nuclei transcriptomics and spatial transcriptomics to explore intra\-tumor heterogeneity and plasticity. Furthermore, we generate novel tumor mouse model systems and include human tumors to perform comparative differentiation trajectory analysis, to make predictions and, finally, to perform preliminary validations of envisioned tumor differentiation strategies.

For examples of how the research can be conducted, please see:

https://pubmed.ncbi.nlm.nih.gov/34493726/

https://pubmed.ncbi.nlm.nih.gov/35760869/

https://pubmed.ncbi.nlm.nih.gov/33385330/

Your profile

To be eligible for employment as a postdoctoral researcher, a PhD or a foreign degree deemed to be equivalent to a Swedish PhD is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. Completion of your doctoral degree within the last three years is considered an advantage. If there are special reasons, your degree may have been completed earlier.

Qualifications:

We are looking for a highly self\-motivated person with a strong background in cellular and molecular biology with a keen interest in nervous system tumors.

Experience in mitochondrial biology, molecular and cellular biology techniques, confocal imaging and mouse modeling is highly desired; and good ability to communicate in English (written and verbal) is required.

A documented ability to independently carry out experimental research projects is required

We are looking for independent and driven candidates who have at least one first\-name publication in a peer\-reviewed journal.

The successful applicants may have experience in one or several of the following techniques/models: Molecular, cellular and biochemical techniques, e.g. cloning, qPCR, Western blot and immunohistochemistry, Bioinformatics, mouse as a model system, Organoid cultures, Mitochondria research

Merits:

It is considered as a merit if the applicant has experience in flow cytometry, imaging, laboratory animal work or bioinformatics analysis tools.

What do we offer?

A creative and inspiring environment with wide\-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

*Choose to work at KI – Ten reasons why*

Application

An employment application must contain the following documents in English or Swedish:

PhD certificate

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work

A complete list of publications

A summary of current work (no more than one page)

KI applies individual and differentiated salary setting in accordance with our collective agreements RALS and RALS\-T

The application is to be submitted through the Varbi recruitment system. Apply at the latest 24th June.

The employment is for 2 years with possibility of extension.

Want to make a difference? Join us and contribute to better health for all!
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