Associate Director, Biostatistics
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<p>Ironwood Pharmaceuticals is a leading global gastrointestinal (GI) healthcare company on a mission to advance the treatment of GI diseases and redefine the standard of care for GI patients. We are pioneers in the development of LINZESS® (linaclotide), the U.S. branded prescription market leader for adults with irritable bowel syndrome with constipation or chronic idiopathic constipation. Ironwood is also advancing apraglutide, a next-generation, long-acting synthetic GLP-2 analog being developed for rare gastrointestinal diseases, including short bowel syndrome with intestinal failure. Building upon our history of GI innovation, we keep patients at the heart of our R&D and commercialization efforts to reduce the burden of GI diseases and address significant unmet needs. </p>
<p>Founded in 1998, Ironwood Pharmaceuticals is headquartered in Boston, Massachusetts, and has operations in Basel, Switzerland</p>
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<p><strong><span data-contrast="auto"><span data-ccp-parastyle="Body Text">Purpose/Summary:</span></span></strong><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></p>
<p><span data-contrast="auto"><span data-ccp-parastyle="Body Text">The Associate Director, Biostatistics</span><span data-ccp-parastyle="Body Text">,</span> <span data-ccp-parastyle="Body Text">is responsible for</span><span data-ccp-parastyle="Body Text"> providing strategic, methodological, and operational statistical leadership </span><span data-ccp-parastyle="Body Text">to create value at Ironwood.</span> <span data-ccp-parastyle="Body Text">The role partners closely with cross-functional teams to shape clinical development strategies and contributes to the design, analysis, interpretation, and communication of clinical data through development plans, study protocols, statistical analysis plans, clinical study reports, regulatory submissions, publications, and business development activities.</span> <span data-ccp-parastyle="Body Text">The Associate Director ensures scientific rigor, data-driven decision-making, and alignment with overall product development </span><span data-ccp-parastyle="Body Text">objectives</span><span data-ccp-parastyle="Body Text">.</span></span><span data-ccp-props="{"201341983":0,"335559738":120,"335559739":0,"335559740":240}"> The position is a hybrid position located onsite at our office in Basel, Switzerland.</span></p>
<p><span data-contrast="auto"><span data-ccp-parastyle="Body Text">Additional </span><span data-ccp-parastyle="Body Text">responsibilities include maintaining expertise in applicable regulatory guidance and industry best practices and promoting compliance through</span><span data-ccp-parastyle="Body Text"> SOP development and training; leading the </span><span data-ccp-parastyle="Body Text">evaluation</span><span data-ccp-parastyle="Body Text"> and </span><span data-ccp-parastyle="Body Text">implementation </span><span data-ccp-parastyle="Body Text">of </span><span data-ccp-parastyle="Body Text">innovative</span><span data-ccp-parastyle="Body Text"> statistical methodolog</span><span data-ccp-parastyle="Body Text">ies</span> <span data-ccp-parastyle="Body Text">to</span><span data-ccp-parastyle="Body Text"> support drug development; </span><span data-ccp-parastyle="Body Text">and overseeing external vendors and </span><span data-ccp-parastyle="Body Text">CRO</span> <span data-ccp-parastyle="Body Text">to ensure high quality</span><span data-ccp-parastyle="Body Text">, timely and compliant deliverables</span><span data-ccp-parastyle="Body Text">. </span></span><span data-ccp-props="{"201341983":0,"335559738":120,"335559739":0,"335559740":240}"> </span></p>
<p><strong><span data-contrast="none"><span data-ccp-parastyle="heading 2">Essential Functions: </span></span></strong><span data-ccp-props="{"134245418":true,"134245529":true,"201341983":0,"335559738":160,"335559739":80,"335559740":240,"335572071":4,"335572072":1,"335572073":4278190080,"469789798":"single"}"> </span></p>
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<li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="none"><span data-ccp-parastyle="heading 2">Serves as the lead statistician and primary statistical representative for assigned clinical studies, providing statistical leadership for study design, </span><span data-ccp-parastyle="heading 2">protocol</span><span data-ccp-parastyle="heading 2"> development</span><span data-ccp-parastyle="heading 2">, sample size </span><span data-ccp-parastyle="heading 2">determination, power calculations for complex study designs, generation of randomization schedule, data sources, statistical analysis plans, clinical study reports, and regulatory interactions;</span></span><span data-ccp-props="{"134245418":true,"134245529":true,"201341983":0,"335559685":0,"335559731":0,"335559738":120,"335559739":80,"335559740":240,"469777462":[360],"469777927":[0],"469777928":[8]}"> </span></li>
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<li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="2" data-aria-level="1"><span data-contrast="none"><span data-ccp-parastyle="heading 2">Provides statistical inputs to </span><span data-ccp-parastyle="heading 2">clinical development plans, regulatory strategies, and life cycle planning</span><span data-ccp-parastyle="heading 2">;</span></span><span data-ccp-props="{"134245418":true,"134245529":true,"201341983":0,"335559685":0,"335559731":0,"335559738":120,"335559739":80,"335559740":240,"469777462":[360],"469777927":[0],"469777928":[8]}"> </span></li>
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<li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="3" data-aria-level="1"><span data-contrast="none"><span data-ccp-parastyle="heading 2">Provides statistical consultations and strategic input </span><span data-ccp-parastyle="heading 2">to</span><span data-ccp-parastyle="heading 2"> senior management and </span><span data-ccp-parastyle="heading 2">cross-functional teams to support drug development decisions;</span></span><span data-ccp-props="{"134245418":true,"134245529":true,"201341983":0,"335559685":0,"335559731":0,"335559738":120,"335559739":80,"335559740":240,"469777462":[360],"469777927":[0],"469777928":[8]}"> </span></li>
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<li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="4" data-aria-level="1"><span data-contrast="none"><span data-ccp-parastyle="heading 2">Develops statistical analysis plans for studies, performs complicated statistical analyses, and oversees the generation of tables, listings and figures for </span><span data-ccp-parastyle="heading 2">clinical </span><span data-ccp-parastyle="heading 2">study reports</span><span data-ccp-parastyle="heading 2">, regulatory submission,</span><span data-ccp-parastyle="heading 2"> and </span><span data-ccp-parastyle="heading 2">publications </span><span data-ccp-parastyle="heading 2">ensuring high-quality, and consistent statistical deliverables;</span></span><span data-ccp-props="{"134245418":true,"134245529":true,"201341983":0,"335559685":0,"335559731":0,"335559738":120,"335559739":80,"335559740":240,"469777462":[360],"469777927":[0],"469777928":[8]}"> </span></li>
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<li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="5" data-aria-level="1"><span data-contrast="none"><span data-ccp-parastyle="heading 2">Provides oversight of external vendors and CRO partners to ensure high-quality, </span><span data-ccp-parastyle="heading 2">timely</span><span data-ccp-parastyle="heading 2">, and compliant statistical deliverables and services;</span></span><span data-ccp-props="{"134245418":true,"134245529":true,"201341983":0,"335559685":0,"335559731":0,"335559738":120,"335559739":80,"335559740":240,"469777462":[360],"469777927":[0],"469777928":[8]}"> </span></li>
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<li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="6" data-aria-level="1"><span data-contrast="none"><span data-ccp-parastyle="heading 2">Reviews regulatory documents for accuracy and appropriateness of statistical </span><span data-ccp-parastyle="heading 2">methodologies and </span><span data-ccp-parastyle="heading 2">interpretations</span><span data-ccp-parastyle="heading 2"> and serves as</span><span data-ccp-parastyle="heading 2"> statistical liaison </span><span data-ccp-parastyle="heading 2">with </span><span data-ccp-parastyle="heading 2">regulatory a</span><span data-ccp-parastyle="heading 2">uthorities;</span></span><span data-ccp-props="{"134245418":true,"134245529":true,"201341983":0,"335559685":0,"335559731":0,"335559738":120,"335559739":80,"335559740":240,"469777462":[360],"469777927":[0],"469777928":[8]}"> </span></li>
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